报 告 人：Prof. Jaebum Choo Bionano Engineering, Hanyang University,
South Korea 报告题目：Development of SERS-based assay platforms for
highly sensitive biomarker detection时
Jaebum Choo is a distinguished professor in the department of Bionano
Engineering,Hanyang University.Research Interests- Early Disease
Diagnosis Using Highly Sensitive Nanoprobe-based Optical Sensor-
Development of Microfluidic Devices for Sensitive Biomarker Detection-
Fabrication of Optically Sensitive Nanoparticles for Sensitive
Biomedical Diagnostics- Development of Portable Nano-biosensor for
Hazardous Virus/Bacteria Pathogens- Development of Integrated Optical
System Combined with SERS-based Lateral Flow KitRepresentative
Achievements Total Number of Peer-Reviewed SCI Papers: 240 (including
ACS Nano, Chem. Soc. Rev., J. Am. Chem. Soc., Anal. Chem., Lab Chip,
Small, Chem. Commun., Nano Lett., Nanoscale, Langmuir, Biosens.
Bioelectron., J. Phys. Chem., J. Chem. Phys. and so on)Contributed Book
Chapters: 5Patents: 32 (Registration: 15, Pending: 17)Invited Lectures:
International 95; Domestic 120Technology Transfer to Industry:
3报告摘要：Lateral flow assay (LFA) strip biosensors are simple devices
intended to detect the presence of a target biomarker in a clinical
fluid. The benefits of LFA biosensors include short times to obtain test
results, a user-friendly format, low cost, and long-term stability.
However, they possess major limitations in terms of quantitative
analysis and detection sensitivity. To resolve these problems, many
different types of optical readers in combination with a LFA strip for
the detection of fluorescence, chemi-luminescence and electrochemical
signals have been employed but they still suffer from poor sensitivity
and low precision. Our research group recently developed several
different types of surface-enhanced Raman scattering (SERS)-based assay
platforms for the highly sensitive biomarker detection [1-3]. We
believe that our proposed SERS-based assay platforms, which possess both
high sensitivity and quantitative evaluation capability, show
significant potential for the rapid and sensitive detection of target
markers in a simplified manner. In this presentation, the current
advances of SERS-based assay platforms and their application potential
in biomedical diagnostics and food engineering will be discussed. First,
the development of SERS-based microfluidic platforms has attracted
significant recent attention in the biomedical sciences. SERS is a
highly sensitive detection modality, with microfluidic platforms
providing many advantages over microscale methods, including high
throughput, facile automation and reduced sample requirements.
Accordingly, the integration of SERS with microfluidic platforms offers
significant utility in chemical and biological experimentation. Herein,
we report a fully integrated SERS-based microdroplet platform for the
automatic immunoassay of specific target antigens. Second, I will
present a SERS-based mapping technique for the highly sensitive and
reproducible analysis of multiple mycotoxins. Raman images of three
mycotoxins, ochratoxin A (OTA), fumonisin B (FUMB), and aflatoxin B1
(AFB1) have been obtained by rapidly scanning the SERS
nanotags-anchoring mycotoxins captured on a three-dimensional (3D)
nanopillar plasmonic substrate. This strong enhancement effect made it
possible to perform a highly sensitive detection of multiple mycotoxins.
Consequently, this made it possible to gain a highly reproducible
quantitative analysis of mycotoxins. We anticipate that these SERS-based
assay platforms provide new insights in the development of facile assay
platforms for various hazardous materials. J. Choo et al.
Simultaneous detection of dual prostate specific antigens using
SERS-based immunoassay for accurate diagnosis of prostate cancer ACS
Nano, 11, 4926-4933 (2017). J. Choo et al. Fluorescent chemical
probes for accurate tumor diagnosis and targeting therapy Chem. Soc.
Rev., 46, 2237-2271 (2017).  J. Choo et al. Sensitive and
Reproducible Immunoassay of Multiple Mycotoxins Using Surface-Enhanced
Raman Scattering Mapping on Three-Dimensional Plasmonic Nanopillar
Arrays Small, 1801623 (2018).附件：无
报告题目：Synthesis and Applications of Novel Two-Dimensional
报告人：Prof. Hua Zhang
School of Materials Science and Engineering, Nanyang Technological
摘要：This seminar will summarize the recent research on synthesis,
characterization and applications of two-dimensional nanomaterials
. It covers the synthesis and characterization of novel
low-dimensional nanomaterials, such as graphene-based composites 
including the first-time synthesized hexagonal-close packed (hcp) Au
nanosheets on graphene oxide , surface-induced phase transformation
of AuSSs from hcp to face-centered cubic (fcc) structures , the
synthesis of ultrathin fcc Au@Pt and Au@Pd rhombic nanoplates through
the epitaxial growth of Pt and Pd on the hcp AuSSs, respectively
, and the epitaxial growth of metal and semiconductor
nanostructures on solution-processable transition metal dichalcogenide
nanoshees at ambient conditions , single- or few-layer metal
dichalcogenide nanosheets  and hybrid nanomaterials , the
large-amount, uniform, ultrathin metal sulfide and selenide nanocrystals
, other 2D nanomaterials , nanodots prepared from 2D
nanomaterials , and self-assembled 2D nanosheets  and chiral
nanofibers from ultrathin low-dimensional nanomaterials . Later
on, the applications of these novel nanomaterials in chemical and
bio-sensors , solar cells , water splitting , hydrogen
evolution reaction [6, 8d,e], electric devices , memory devices
, conductive electrodes [14b, 15, 17a, 18a,b, 19], other clean
energy , etc will be demonstrated.
Keywords: Two-dimensional nanomaterials; Graphene; Metal
dichalcogenides; Nanodevices; Field-effect transistors; Sensors; Clean
 X. Huang, et al., Chem. Soc. Rev., 2012, 41, 666. X.
Huang, et al., Chem. Soc. Rev., 2013, 42, 1934. X. Huang, et
al., Adv. Mater., 2014, 26, 2185. H. Li, et al., Acc. Chem.
Res., 2014, 47, 1067. X. H. Cao, et al., Energ. Environ. Sci.,
2014, 7, 1850. H. Li, et al. ACS Nano, 2014, 8, 6563. C.
L. Tan, et al. Chem. Soc. Rev., 2015, 44, DOI:
10.1039/c4cs00182f. Y. Chen, et al., Chem. Soc. Rev., 2015, 44,
DOI: 10.1039/C4CS00300D. C. L. Tan, et al., Chem. Soc. Rev., 2015,
 X. Y. Qi, et al., Angew. Chem. Int. Ed., 2010, 49, 9426.
X. Y. Qi, et al., Adv. Mater. 2012, 24, 4191. X. H. Cao, et al.
Angew. Chem. Int. Ed., 2014, 53, 1404.
 X. Huang, et al., Nat. Commun. 2011, 2, 292. X. Huang, et
al., Angew. Chem. Int. Ed. 2011澳门新葡亰，, 50, 12245. X. Huang, et al.,
Adv. Mater. 2012, 24, 979.
 Z. X. Fan, et al., Nat. Commun., 2015, 6, 6571.
 Z. X. Fan, et al., Angew. Chem. Int. Ed., 2015, DOI:
 X. Huang, et al. Nat. Commun. 2013, 4, 1444; C. L. Tan, et
al. Angew. Chem. Int. Ed., 2015, 54, 1841.
 Z. Y. Zeng, et al. Angew. Chem. Int. Ed. 2011, 50, 11093.
Z. Y. Zeng, et al. Angew. Chem. Int. Ed. 2012, 51, 9052. Z. Y.
Yin, et al. ACS Nano 2012, 6, 74. H. Li, et al. ACS Nano
2013, 7, 2842. Y. Y. Zhao, et al. Nano Lett. 2013, 13,
- H. Li, et al. ACS Nano, 2013, 7, 10344. H. Li, et al. ACS
Nano, 2014, 8, 6563.
 Z. Y. Yin, et al., Angew. Chem. Int. Ed., 2014, 53, 12560.
X. Hong, et al. Adv. Mater., 2014, 26, 6250. X. Huang, et al.,
ACS Nano, 2014, 8, 8695. J. Z. Chen, et al., Angew. Chem. Int.
Ed., 2015, 54, 1210. Z. Y. Zeng, et al. Energy Environ. Sci.,
2014, 7, 797.
 Y. P. Du, et al. Nat. Commun. 2012, 3, 1177. X. J. Wu, et
al. Angew. Chem. Int. Ed. 2014, 53, 5083. X. J. Wu, et al.
Angew. Chem. Int. Ed. 2014, 53, 8929.
 D. Yang, et al., Angew. Chem. Int. Ed., 2014, 53, 9352.
 X. Zhang, et al., Angew. Chem. Int. Ed., 2015, 54, 3653. X.
Zhang, et al., Angew. Chem. Int. Ed., DOI: 10.1002/anie.201501071.
 X. Hong, et al. J. Am. Chem. Soc., 2015, 137, 1444.
 C. L. Tan, et al., J. Am. Chem. Soc., 2015, 137, 1565.
 Q. Y. He, et al., ACS Nano, 2010, 4, 3201. Q. Y. He, et
al., ACS Nano, 2011, 5, 5038. H. G. Sudibya, et al., ACS Nano,
2011, 5, 1990. C. F. Zhu, J. Am. Chem. Soc., 2013, 135,
- Y. Zhang, et al., Adv. Mater., 2015, 27, 935.
 Z. Y. Yin, et al. Adv. Energy Mater., 2014, 4, 1300574.
Z. Y. Yin, et al., ACS Nano, 2010, 4, 5263.
 Z. Y. Yin, et al., Adv. Mater. 2012, 24, 5374.
 B. Li, et al., Adv. Mater., 2010, 22, 3058. Z. Y. Zeng,
et al., Adv. Mater., 2012, 24, 4138.
 J. Q. Liu, et al., ACS Nano, 2010, 4, 3987. J. Q. Liu, et
al. Adv. Mater. 2013, 25, 233. F. Zhao, et al., ACS Nano,
2012, 6, 3027. G. Z. Sun, et al. Angew. Chem. Int. Ed.,
2013, 52, 13351.
 X. Huang, et al., Adv. Mater., 2012, 24, 5979.
 G. Z. Sun, et al., Angew. Chem. Int. Ed., 2015, 54, 4651.
G. Z. Sun, et al., Angew. Chem. Int. Ed., 2014, 53, 12576. W. J.
Zhou, et al., Energy Environ. Sci., 2013, 6, 2216.
Dr. Hua Zhang obtained his B.S. and M.S. degrees at Nanjing University
in China in 1992 and 1995, respectively, and completed his Ph.D. with
Prof. Zhongfan Liu at Peking University in China in July 1998. He joined
Prof. Frans C. De Schryver’s group at Katholieke Universiteit Leuven in
Belgium as a Research Associate in January 1999. Then he moved to Prof.
Chad A. Mirkin’s group at Northwestern University as a Postdoctoral
Fellow in July 2001. He started to work at NanoInk Inc. as a Research
Scientist/Chemist in August 2003. After that, he worked as a Senior
Research Scientist at Institute of Bioengineering and Nanotechnology in
Singapore from November 2005 to July 2006. Then he joined the School of
Materials Science and Engineering in Nanyang Technological University as
an Assistant Professor. He was promoted to a tenured Associate Professor
on March 1, 2011, and Full Professor on Sept. 1, 2013.
He has published 5 invited book chapters, 55 patent applications
(including 8 granted US patents), and over 310 papers, among
which 287 papers were published in the journals with IF>3
(including 113 papers published in IF>10 journals and 57
papers published in 7<IF<10 journals). Some of his papers have
been published in *Science, Nat. Chem., Nat. Commun., Chem. Soc. Rev.,
Acc. Chem. Res., Angew. Chem. Int. Ed., Adv. Mater., J. Am. Chem. Soc.,
Nano Lett., ACS Nano, Adv. Energy Mater., Energy Environ. Sci., Adv.
Funct. Mater., Chem. Sci., Chem. Mater., Small**, etc. Based on Web
of Science on Feb. 27, 2015, the total citation of his papers is over
16,200 with H-index of 64. He has been invited to give more than
180 Plenary, Keynote or Invited Talks in many international
conferences, universities and institutes, and serve as Session Chair. He
has organized several international conferences and served as Symposium
Chair or Conference Co-Chair. He is one of the Chairmen of the Editorial
Board of **ChemNanoMat and an Associate Editor of International
Journal of Nanoscience , sits on the Advisory Board of Chem. Soc.
Rev. and Nanoscale , the Editorial Advisory Board of ACS
Nano , Chem. Mater. , ACS Appl. Mater.* **
Interfaces * , Small and Nanofabrication , the
Editorial Board of Carbon , Applied Materials Today ,Energy Storage Materials and NANO , and the International
Advisory Board of Materials Research Express andChemPlusChem . He is also one of the members of the Advisory
Committee of IOP Asia-Pacific . In Nov. 2014, he was elected as aFellow of Royal Chemical Society (FRSC). Moreover, he was
selected to The World’s Most Influential Scientific Minds and theHighly Cited Researchers 2014* (Thomson Reuters, 2014) and listed
as one of 17 “Hottest Researchers of Today” in the world, and got
the World Cultural Council Special Recognition Award (2013), the
ONASSIA Foundation Lectureship (Greece, 2013), Asian Rising
Stars (15th Asian Chemical Congress, 2013), SMALL Young Innovator
Award (Wiley-VCH, 2012) and Nanyang Award for Research Excellence
Dr. Zhang’s research is highly interdisciplinary. His current research
interests focus on synthesis of two-dimensional nanomaterials (graphene
and transition metal dichalcogenides), carbon materials (graphene and
CNTs) and their hybrid composites for various applications in nano- and
biosensors, clean energy, water remediation, etc.; controlled
synthesis, characterization and application of novel metallic and
semiconducting nanomaterials; scanning probe microscopy;
lithography-based fabrication of surface structures from micro- to
nanometer scale; self-assembly and self-organization of nano- and
biomaterials; self-assembled monolayers; etc.